Activation is in what order Jokers trigger their effects. Due to the integral Activation Sequence, Joker effects with different activation types can interact very differently.
Joker activation types[]
On Played[]
Joker effects that activate immediately when you play cards, and before scoring. These are often scaling abilities: for example 
Square Joker's scaling, 
Runner's scaling, 
Vampire's scaling, 
Space Joker, 
DNA, and 
Midas Mask. These effects benefit from playing more required hands or cards. Note that these affect unscored cards.
On Scored[]
Joker effects that activate on every scored card from your played hand: for example 
Wrathful Joker, 
Odd Todd, 
The Idol, 
Wee Joker's scaling, and 
Dusk. Since they activate on card triggers, they would benefit greatly from card retriggers (except other retriggers), and be hindered by cards not scored or debuffed.
On Held[]
Joker effects that activate on certain cards held in hand: for example 
Raised Fist, 
Baron, 
Reserved Parking, and 
Mime. They benefit from retriggers from Mime (except for itself) and are affected by debuffs.
Independent[]
Joker effects that happen after all the cards in hand are scored: for example 
Joker, 
Sly Joker, 
Steel Joker. Editions on Jokers like foil, holographic or polychrome also activate during this phase. These Jokers do not get affected by retriggers or card debuffs in most cases.
On Other Jokers[]
Joker effects that activate on certain other Jokers. Only 
Baseball Card activates this way as of now.
On Discard[]
Joker effects that activate on discarding certain cards or poker hands. There are a few categories: 
Burnt Joker and 
Faceless Joker rely on discarding poker hands; 
Castle's scaling and 
Mail-In Rebate rely on discarding specific cards. Benefits from having more discards, but doesnāt have much synergy besides that.
Mixed[]
Jokers that belong to multiple other categories, such as Runner belonging to both "On Played" for scaling, and "Independent" for adding chips to the total score.
N/A (Passive)[]
Some non-scoring Jokers fit in none of the above categories, mostly Economy Jokers like 
Credit Card, or Effect Jokers like 
Four Fingers.
Strategy[]
Since on-scored Jokers and on-held Jokers always activate before independent Jokers, the xMult from on-scored Jokers and +Mult from independent Jokers donāt activate in the optimal order. For example, 
Droll Joker cannot benefit from 
Ancient Joker when a flush with the selected suit is played.
List of Jokers[]
Extensive list of Activation type for each Joker. Is not automatically updated, so might mismatch with an individual Joker's page.
Table Keys:
| +c | adds to current chips total |
| +m | adds to current mult total |
| Xm | multiplies current mult total |
| ++ | adds to both chips and mult current totals |
| !! | applies some effect |
| ... | retrigger ability |
| +$ | adds to money |
| āā | positive scaling |
| āā | negative scaling |
| āā | positive scaling but can reset |
| į£ | (death rune) will destroy itself |
| į£? | (death rune) chance to destroy itself |
| į | has a requirement to activate |
